Talk Title: Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect
Position: Professor，Deputy-director of the department of pharmaceutical analysis
Organization: Institute of Materia Medica, Chinese Academy of Medical Sciences, 2 NanweiI Road, Xuanwu District, Beijing, 100050
E-mail: [email protected]
Educational Background
- PhD candidate in pharmaceutical analysis, 09/1999-07/2002，Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College( PUMC)
- MS in pharmaceutical analysis, 09/1992-07/1995，Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Science, PUMC
- BS in Pharmacy, 09/1987-07/1992，College of Pharmacy, Beijing University
Degree and Major: PH.D, Pharmaceutical Analysis
Research Experience:
- Metabolism of new drugs and nature products by hybrade tandem mass spectrometry techniques
- Develop new metabolonics/proteomics analytical method for biomarkers related to desease
- Develop new analytical techniques to detect drug in biological samples for pharmacokinetic study of new drugs and leader compounds
Work Experience:
- 09/2000-07/2002，Associated professor，Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College( PUMC)
- 08/2002-05/2004，Post Doctor, College of Pharmacy, Beijing University
- 06/2004 to now， Associated professor and professor，Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College( PUMC)
Resent Publications:
1.Ning Sheng# , Rui Li#, Yang Li , Zhe Wang, Lulu Wang , Yuhuan Li, Jinlan Zhang* , Jiandong Jiang *Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect，Acta Pharm Sin B，2024，14: 3140
2. Sheng N#, Zhang Z#, Zheng H#, Ma C, Li M, Wang Z, Wang L, Jiang J*, Zhang J*. Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis. Adv Sci (Weinh). 2023 ，10(32):e2303584
3. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide[J]. Journal of Pharmaceutical Analysis, 2020. doi.org/10.1016/j.jpha.2020.08.008
4 .Zhang JL, Li YH, Wang LL, et al，Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients，Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Target Ther. 2021，6(1):414
5.Mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamster. Miao Lin, Zhe Wang , Dongmei Wang, Xiong Chen, Jin-Lan Zhang*. Analytical chemistry, 2019, 91: 4504-4512.